Zebra ZD421-HC

Zebra ZD421-HC

Category | Printers
Type | Healthcare Desktop Printers

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Zebra's advanced healthcare desktop printers

You need an reliable label printer that is built for healthcare that delivers quality performance, now and for years to come.  The Zebra ZD421-HC 4" desktop printer is easy to set up, operate, manage and maintain.  Plus, is easy to clean, sanitize and safely power.  It is secure to protect patient information, whether integrated onto your network or not, to prevent downtime and costly cyberattacks. 


The Zebra ZD421-HC desktop printer is available in a thermal transfer (roll ribbon), direct thermal printing (no ribbon) and a ribbon cartridge model with simple ribbon loading. 


With virtually every modern wired and wireless connectivity option and support for many printer languages, deployment is always fast and easy.  Just unplug your existing printer, plug in the ZD421-HC and you're back up and running.


The ZD421-HC can be turned into a portable printer on a cart or with optional carry case and battery.


Groundbreaking Ease of Use:  The Zebra ZD421-HC is loaded with features that make it the easiest printer to use in its class. The ZD421-HC is the only thermal transfer printer to offer a ribbon cartridge, which takes just a few seconds to load with fool-proof installation.  The crypto chip in the ribbon lets you know when the ribbon needs replacing. And with five status icons, your works can see at a glance what is needed to keep your Zebra printer up and running.


Easy to Clean and Sanitize Healthcare Model:  The ZD421-HC is available in a healthcare model with disinfectant-ready plastics and a sealed button interface that makes it easy to clean and disinfect.  The ZD421-HC fits easily in space constrained pharmacies, labs and nurses stations.  And with its 300 dpi printing option, even the small labels on specimen containers and prescriptions are highly legible.



  • Healthcare white color
  • Print speed: Up to 6"/152 mm per second at 203 dpi / 4"/102 mm per second at 300 dpi
  • Print method: Thermal transfer, direct thermal
  • 5 status icon, 3 button user interface
  • Resolution: 203 dpi (8 dots/mm) with optional 300 dpi (12 dots/mm)
  • Memory: 512 MB Flash/ 256 MB SDRAM
  • Print width: 4.09" (104 mm) for 203 dpi and 4.27" for 300 dpi, 4.09" for cartridge 203/300 dpi
  • Label length: .25" to 39" (991 mm)
  • Ribbon: Cartridge or Roll
  • EPL and ZPL programming languages standard
  • OpenACCESS design for easy media loading
  • Real time clock
  • Dual-wall reinforced disinfectant-ready plastic construction
  • Dimensions: Thermal Transfer Cartridge: 10" l x 8" w x 7" h (254 x 202 x 177 mm)
  • Dimensions:  Direct Thermal:  8.69" l x 6.98" w x 5.93" h (220.8 x 177.5 x 150.7mm)
  • Weight: Thermal Transfer Cartridge: 5 lbs./2.3 kg.
  • Weight:  Direct Thermal:  2.98 lbs.
  • Accessories include battery, carrying case, keyboard display unit, mounting plate and enclosed power supply

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